摘要:目的;观察分析淋巴瘤患者Wbc、Hb、Pc、ESR与淋巴瘤分期，临床特征以及愈后转归的关系。方法 ：检查分析52例淋巴瘤初诊病例Wbc、Hb、Pc、ESR并分析结果。结果：有B症状组，Hb、Pc、ESR均低于无B症状组；Ⅲ Ⅳ期患者的Hb明显低于ⅠⅡ患者（P<0.05), ESR高于ⅠⅡ患者（P<0.01)；骨髓侵润患者Pc低于无骨髓侵润患者（P<0.05), Hb骨髓侵润患者低于无骨髓侵润患者，ESR高于无骨髓侵润患者，但P都大于0.05，无统计学意义；Wbc、Lc绝对值观察各组均未见统计学意义的改变。结论: Wbc、Hb、Pc、ESR与淋巴瘤分期，临床特征以及治疗后转归具有一定的关系,特别是Hb、ESR可作为观察病情进展和转归的重要指标.

Analysis of WBC、ALc、Hb、PC、ESR and Clinical pathology characteristic in non-Hodgkin’s lymphoma (NHL)

Wang hongling School of medicine and life science, University of Jinan –shandong  academy of medical sciences,

 Bi kehong* correspondence author   Department of Hematology ,Shandong qianfoshan hospital.   

Abstract

 Aims: Observation and analysis the relationship of lymphoma patients’ Wbc, Hb, Pc, ESR with their disease stage and progression . Methods : examation of 52 lymphoma patients and analysis the results of Wbc, Hb, Pc, ESR. Results: Wbc and LC absolute count have no significance of statistics among any groups . the group with B symptom that the results of Hb, Pc are lower than that of no B symptom, ESR is higher than that of  no B symptom patients, but no statistics significance ; the patients in stage Ⅲ/Ⅳwith lower Hb than that of stage Ⅰ/Ⅱpatients (P<0.05),ESR is higher than that of stage Ⅰ/Ⅱpatients(P<0.01); Patients with bone marrow involvement have lower Pc and Hb than that patients with bone marrow involvement  (Pc P<0.05,but Hb P >0.05) ,ESR is also high in patients with bone marrow involvement(but P>0.05),no statistics significance ; Conclusion : WbcLc、Hb、Pc、ESR  have the relationship in lymphoma patients’stage and progression of disease, Hb、Pc、ESR could be important indicators to observation and prediction process of lymphoma patients befor or after  treatement.

1 资料来源  回顾性分析初诊非淋巴瘤患者52例。52例患者中。男性30例，女性22例，平均年龄56.6岁。所有患者在规范治疗前常规检查血常规、血生化、血沉。所有患者均经过组织病理活检，骨髓穿刺细胞学检查和骨髓活检检查以及内外科综合检查确诊为淋巴瘤。

1.1 病变病理学特点和临床分期

 按2008年WHO卫生组织淋巴瘤诊断标准，52例非何奇金淋巴瘤,其中节内淋巴瘤33例，节外淋巴瘤19例。最常见的NHL淋巴瘤节外累及器官是胃肠道9例，依次是纵隔3例，鼻和脾脏各2例，肝脏、舌根，腮腺，炉房，睾丸各1例。

1.1.2   病理学特点

非何奇金淋巴瘤DLBCL发病率最高16例28.85%、富T细胞的B细胞淋巴瘤7例、周围B细胞淋巴瘤6例、T-淋巴母细胞淋巴瘤4例、血管母细胞淋巴瘤、滤泡性淋巴瘤各3例、简变性大细胞淋巴瘤、NK/T-细胞淋巴瘤、慢性B细胞白血病/小淋巴细胞、B淋巴细胞白血病/淋巴瘤各2例、前趋T细胞淋巴瘤、周围T细胞淋巴瘤、套细胞淋巴瘤、浆细胞淋巴瘤、BURKITT各1例。

1.1.3  临床分期

依据2008年WHO卫生组织AnnArbor淋巴瘤分期标准。根据临床病理特点、分期、有/无骨髓浸润等分组。有B症状13例、无B症状39例, 临床分期I/II期 17例、III /IV期35例、骨髓浸润19例、无骨髓浸润33例, 根据国际预后指标（IPI）以及临床症状危险程度分组: 低危9例、中低危20例、中危16例、高危7例。

2  统计学处理：应用统计学软件SPSS15.0处理,均数用`X±SD表示,P<0.05示有统计学意义。

3  结果